Recombinant Human GIF protein (N-His)
Product Specifications
Background
Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric intrinsic factor plays a key role in the absorption of vitamin B12 on in the small intestine. Vitamin B12 bounds to haptocorrin after entry into the stomach. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to gastric intrinsic factor. This new complex travels to the ileum, where special epithelial cells endocytose them. Inside the cell, B12 dissociates once again and binds to another protein, transcobalamin II. The new complex can exit the epithelial cells to enter the liver.
Abbreviation
GIF
Synonyms
CBLIF; IF; IFMH; INF; TCN3
UniProt
P27352
Accession Number
P27352
Expression System
E.coli
Tag
C-His
Sequence
Met 1-Tyr 417
Field of Research
Signal Transduction, Metabolism
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method.
Purity
> 98 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/0dwpd1
Product MSDS
https://789.bio/eb/98WTG8
Calculated Molecular Weight
46.2 kDa
Observed Molecular Weight
45 kDa
Species
Human
Available Sizes
Curated Selection
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