Recombinant Human AITRL protein (His Tag)

Product Specifications

Background

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.

Abbreviation

AITRL

Synonyms

GITRL; TL6; TNFSF18; TNLG2A; hGITRL

UniProt

Q9UNG2

Accession Number

Q9UNG2

Expression System

E.coli

Tag

C-His

Sequence

Gln 50-Ile 176 (L170I, F175E)

Applications

Cell culture

Field of Research

Immunology, Tags & Cell Markers, Signal Transduction, Cancer, Cardiovascular

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 98 % as determined by reducing SDS-PAGE.

Bioactivity

Measure by its ability to induce IL-8 secretion in human PBMC using a concentration range of 5-200 ng /mL. Note: Result may vary from different PBMC donors.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.