Recombinant Human IL-24 protein (His Tag)

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I intereferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2.

MDA; MOB; Melanoma Differentiation Association Protein; IL24; C49A; FISP; IL10B; MDA7; MOB5; ST16; MDA-7 (Melanoma Differentiation-Associated gene 7 protein) ; Melanoma Differentiation Association Protein 7; IL 24; IL 4 induced secreted protein; IL-24; interleukin 24; Interleukin-24; MDA-7; Melanocyte associated Mda 7; Melanoma differentiation-associated gene 7 protein; Suppression of tumorigenicity 16; Suppression of tumorigenicity 16 (melanoma differentiation) ; Suppression of tumorigenicity 16 protein

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.