Recombinant Human IL-16 (129 a.a.) protein (N-His)

Product Specifications

Background

Interleukin-16 (IL-16) is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.

Abbreviation

IL-16

Synonyms

NIL; Interleukin; IL16; LCF; NIL16; PRIL16; prIL-16; IL-16; Interleukin-16; LCF (Lymphocyte Chemoattractant Factor) ; Lymphocyte chemoattractant factor; Pro-Interleukin-16

UniProt

Q14005

Accession Number

Q14005

Expression System

E.coli

Tag

C-His

Sequence

Met 1203-Ser 1332

Field of Research

Immunology

Endotoxin

< 0.1 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.