Recombinant Human TNFRSF8/CD30L Receptor/CD30 (C-mFc)
Product Specifications
Background
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL) . CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.
Abbreviation
TNFRSF8; CD30L Receptor; CD30
Synonyms
CD30; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; TNFRSF8; Tumor necrosis factor receptor superfamily member 8
UniProt
P28908
Accession Number
P28908
Expression System
HEK293 Cells
Tag
C-mFc
Sequence
Phe19-Lys379
Field of Research
Cancer; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/u5thg0
Product MSDS
https://789.bio/eb/KOurXH
Calculated Molecular Weight
64.8 kDa
Observed Molecular Weight
90-120 kDa
Species
Human
Available Sizes
Curated Selection
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