Recombinant Human CD59 (C-6His)

CD59, also known as membrane attack complex inhibition factor (MACIF), Protectin, 1F5 antigen, HRF-20 and MIRL, is an approximately 20 kDa GPI anchored glycoprotein that is an important regulator of the complement system in blood. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

16.3A5;1F5;1F5 antigen;20 kDa homologous restriction factor; CD59; CD59 antigen; CD59 glycoprotein; EL32; FLJ38134; FLJ92039; G344; HRF-20; HRF20; MAC-IP; MACIF; MIC11; MIC11MSK21; MIN1; MIN2; MIN3; MIRL; p18-20

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.