Recombinant Human PVRIG (C-mFc)
Product Specifications
Background
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
Abbreviation
PVRIG
Synonyms
C7orf15; C7orf15MGC138295; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; transmembrane protein PVRIG
UniProt
Q6DKI7
Accession Number
Q6DKI7
Expression System
HEK293 Cells
Tag
C-mFc
Sequence
Thr41-Asp171
Applications
BLI
Field of Research
Cell biology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Loaded Biotinylated Human Nectin-2-His on His Biosensor, can bind Human PVRIG with an affinity constant of 84.68 nM as determined in BLI assay.
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
40.1 kDa
Observed Molecular Weight
45-55 kDa
Species
Human
Available Sizes
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