Recombinant Human SLAM Family Member 5/SLAMF5/CD84 (C-6His-Avi) Biotinylated

SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 amino acid (aa) extracellular domain (ECD) with two Iglike domains, a 21 aa transmembrane segment, and a 99 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs (ITSMs) . CD84 exhibits homophilic binding which is mediated by the N-terminal Ig-like domain. Ligation induces tyrosine phosphorylation in the cytoplasmic ITSMs which then recruit the signaling adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS/Fli1-activated transcript 2) .CD84 signaling inhibits Fc epsilon RI-induced mast cell activation but enhances platelet activation. LPS-induced macrophage activation, T cell proliferation and IFN-γproduction, and the interactions between T cells and B cells that are required for germinal center formation.

HCD; mCD; SLAM family member; Cell surface antigen MAX; Leukocyte differentiation antigen CD; Signaling lymphocytic activation molecule; SLAMF; Cell surface antigen MAX.3; hCD84; Hly9-beta; Leukocyte differentiation antigen CD84; LY9B; mCD84; Signaling lymphocytic activation molecule 5; SLAM family member 5; SLAMF5; CD84; GR6

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.