Recombinant Human Tumor-associated Calcium Signal Transducer 2/TROP-2 (248AA, C-6His)
Selected Variant
PKSH033991-01
Size: 10 µg
Product Specifications
Background
Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.
Abbreviation
TROP-2
Synonyms
Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; TACSTD2; TROP2; Tumor-associated calcium signal transducer 2
UniProt
P09758
Accession Number
P09758
Expression System
HEK293 Cells
Tag
C-His
Sequence
His27-Thr274
Applications
BLI
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Loaded Anti-Human TROP-2 mAb-Fc on Protein A Biosensor, can bind Human TROP-2-His with an affinity constant of 0.21 nM as determined in BLI assay.
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
28.9 kDa
Observed Molecular Weight
40-50 kDa
Species
Human
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