Recombinant Human Galectin-9/LGALS9 (N-GST)
Product Specifications
Background
Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte (Th1) death. In addition, Galectin-9 suppresses tumor cell metastasis by interfering with the associations CD44, VCAM-1, Integrin α4β1
Abbreviation
Galectin-9; LGALS9
Synonyms
Ecalectin; Gal-9; Gal-9delta5; Galectin-9; LGALS9; Tumor antigen HOM-HD-21
UniProt
O00182
Accession Number
O00182-2
Expression System
E.coli
Tag
N-GST
Sequence
Met1-Thr322
Field of Research
Cell Biology, Neuroscience, Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
62.2 kDa
Observed Molecular Weight
60 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 1M PBS, 100 mM GSH, 15% Glycerol, pH 8.0.
Species
Human
Available Sizes
Curated Selection
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