Artefenomel
Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2[1][2].
Product Specifications
CAS Number
1029939-86-3
Product Name Alternative
OZ439
UNSPSC
12352005
Target
Ferroptosis; Parasite; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/artefenomel.html
Purity
99.41
Solubility
DMSO : 4.2 mg/mL (ultrasonic)
Smiles
[H][C@@]1(C[C@H](C2)C3)C4([C@@]3([H])C[C@H]2C1)O[C@]5(OO4)CC[C@H](CC5)C6=CC=C(C=C6)OCCN7CCOCC7
Molecular Formula
C28H39NO5
Molecular Weight
469.61
References & Citations
[1] Joëlle Jourdan, et al. Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel) . ACS Infect Dis. 2016 Jan 8;2 (1) :54-61.|[2]Tania Massignan, et al. Antimalarial Artefenomel Inhibits Human SARS-CoV-2 Replication in Cells while Suppressing the Receptor ACE2.|[3] Robert L Clark, et al. Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate. Birth Defects Res. 2018 Apr 17;110 (7) :553-578.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Plasmodium
Available Sizes
Frequently Asked Questions
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