Artefenomel

Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2[1][2].

Product Specifications

CAS Number

[1029939-86-3]

Product Name Alternative

OZ439

UNSPSC

12352005

Target

Ferroptosis; Parasite; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/artefenomel.html

Purity

99.41

Solubility

DMSO : 4.2 mg/mL (ultrasonic)

Smiles

[H][C@@]1(C[C@H](C2)C3)C4([C@@]3([H])C[C@H]2C1)O[C@]5(OO4)CC[C@H](CC5)C6=CC=C(C=C6)OCCN7CCOCC7

Molecular Formula

C28H39NO5

Molecular Weight

469.61

References & Citations

[1] Joëlle Jourdan, et al. Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel) . ACS Infect Dis. 2016 Jan 8;2 (1) :54-61.|[2]Tania Massignan, et al. Antimalarial Artefenomel Inhibits Human SARS-CoV-2 Replication in Cells while Suppressing the Receptor ACE2.|[3] Robert L Clark, et al. Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate. Birth Defects Res. 2018 Apr 17;110 (7) :553-578.