Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family) . IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9) . Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.

FIL; UNQ; PRO; IL1F; IL1L; IL1HY; IL1RP; PSORS; IL36RN; FIL1; FIL1 (DELTA) ; FIL1D; IL-36Ra; IL1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; PSORP; PSORS14; UNQ1896; PRO4342; FIL1 Delta; IL-1 Delta; IL-1F5; IL-1HY1; IL-1L1; IL-1ra Homolog 1; IL-1-Related Protein 3; IL-1RP3; Interleukin-1 Delta; Interleukin-1 Family Member 5; Interleukin-1 HY1; Interleukin-1 Receptor Antagonist Homolog 1; Interleukin-1-Like Protein 1; Interleukin-36 Receptor Antagonist Protein

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.