Recombinant Human FAM3B (C-Fc)
Product Specifications
Background
FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.
Abbreviation
FAM3B
Synonyms
CDw329; Protein FOAP-9; SIGLEC9; Sialic acid-binding Ig-like lectin 9; Siglec-9
UniProt
P58499
Accession Number
P58499
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Glu30-Ser235
Field of Research
Immunology; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/l4hmp0
Product MSDS
https://789.bio/eb/T4mDmD
Calculated Molecular Weight
50.0 kDa
Observed Molecular Weight
50-65 kDa
Species
Human
Available Sizes
Curated Selection
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