Recombinant Human CTLA4 Protein (Fc & Avi Tag)
Product Specifications
Background
Cytotoxic T-lymphocyte protein 4; is a single-pass type I membrane protein. It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4; together with their ligands; B7-1 and B7-2; constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells; whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Abbreviation
CTLA4
Synonyms
CD152; CTLA4; Cytotoxic T-Lymphocyte-Associated Protein 4; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4
UniProt
P16410
Accession Number
P16410
Expression System
HEK293 Cells
Conjugation
Biotinylated
Tag
C-Fc-Avi
Sequence
Lys36-Asp161
Field of Research
Immunology; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/p4vms0
Product MSDS
https://789.bio/eb/O8CqvH
Calculated Molecular Weight
41.5 kDa
Observed Molecular Weight
57-60 kDa
Species
Human
Available Sizes
Curated Selection
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