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Recombinant Human ASXL1 Protein (GST Tag)

Product Specifications

Background

Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) . It acts as coactivator of RARA and RXRA through association with NCOA1. ASXL1 also acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters.

Abbreviation

ASXL1

Synonyms

ASXL1; Additional sex combs-like protein 1; KIAA0978; Putative Polycomb group protein ASXL1

UniProt

Q8IXJ9

Accession Number

Q8IXJ9

Expression System

E.coli

Tag

N-GST

Sequence

Lys1477-Arg1541

Field of Research

Signal Transduction; epigenetics and nuclear signal

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

33.6 kDa

Observed Molecular Weight

38 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Species

Human

Available Sizes

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