Recombinant Human ALDH1A3 Protein (His Tag)
Product Specifications
Background
Aldehyde dehydrogenase 1 family member A3 (ALDH1A3), also known as retinaldehyde dehydrogenase 3 (RALDH3), is a member of the aldehyde dehydrogenase family known to metabolize a wide variety of aldehydes. ALDH1A3 specifically oxidizes retinal to retinoic acid (RA) and is differentially expressed in developing embryonic tissues and adult organs. The RA produced by ALDH1A3 in rodents contributes to the development of skin and hair follicles, brain, tooth buds, lungs, olfactory bulbs, kidneys, eyes, skeletal muscle and seminal vesicles. In recent research, ALDH1A3 could be as a marker of cancer stem cell to predict metastasis or clinical prognosis in many cancers.
Abbreviation
ALDH1A3
Synonyms
ALDH1A3; ALDH1A6; ALDH6; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; MCOP8; RALDH-3; RALDH3; Retinaldehyde dehydrogenase 3
UniProt
P47895
Accession Number
P47895
Expression System
E.coli
Tag
N-His
Sequence
Met1-Pro512
Field of Research
Signal Transduction; Neuroscience; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
57.5 kDa
Observed Molecular Weight
55-60 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 20% Glycerol, pH 7.5.
Species
Human
Available Sizes
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