Recombinant Human Alpha-Synuclein/SNCA Protein

Product Specifications

Background

Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1; Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition; SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson' s Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB) .

Abbreviation

SNCA

Synonyms

Alpha-Synuclein; NACP; Non-A Beta Component of AD Amyloid; Non-A4 Component of Amyloid Precursor; PARK1; SNCA

UniProt

P37840

Accession Number

P37840

Expression System

E.coli

Tag

None

Sequence

Met1-Ala140

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.