Recombinant Human Fibrillin-1/FBN1 Protein (His Tag)
Product Specifications
Background
Asprosin is a protein hormone that is produced by white adipose tissue in mammals (and potentially by other tissues), which is then transported to the liver and stimulates it to release glucose into the blood stream. In the liver asprosin activates rapid glucose release by a cAMP-dependent pathway. The glucose release by the liver into the blood stream is vital for brain function and survival during fasting. People with neonatal progeroid syndrome lack asprosin, while people with insulin resistance have it in abundance. In animal tests asprosin showed potential for treating type 2 diabetes. When antibodies targeting asprosin were injected into diabetic mice, blood glucose and insulin levels improved.
Abbreviation
Fibrillin-1; FBN1
Synonyms
ECTOL; GPHYSD; MFS; FBN1; ACMICD; ECTOL1; FBN; GPHYSD2; MASS; MFLS; MFS1; OCTD; SGS; SSKS; WMS; WMS2;350 kDa glycoprotein component extracellular microfibril; Asprosin; FBN 1; Fibrillin 15; Fibrillin1; Fibrillin-1; Fibrillin15; Marfan syndrome; MFS 1; Weill Marchesani syndrome; THBD; THRM
UniProt
P35555
Accession Number
P35555
Expression System
HEK293 Cells
Tag
N-His
Sequence
Ser2732-His2871
Field of Research
Signal Transduction
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
17 kDa
Observed Molecular Weight
25-35 kDa
Species
Human
Available Sizes
Documents
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