Recombinant Human BCL2L1/Bcl-XL Protein (His Tag)

Product Specifications

Background

Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.

Abbreviation

BCL2L1; Bcl-XL

Synonyms

Apoptosis Regulator Bcl-X; BCL-XL/S; BCL2L; BCLX; BCLXL; BCLXS; Bcl-2-Like Protein 1; Bcl-X; Bcl2-L-1; PPP1R52; bcl-xL; bcl-xS

UniProt

Q07817

Accession Number

Q07817

Expression System

E.coli

Tag

C-His

Sequence

Met1-Arg212

Field of Research

Signal Transduction; Cell biology; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

24.9 kDa

Observed Molecular Weight

29 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5.

Species

Human

Available Sizes

Documents

Product Datasheet

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