Recombinant Human BCMA/TNFRSF17 Protein (Fc Tag)

Product Specifications

Background

B cell maturation protein (BCMA) is a type III membrane protein which belongs to the TNF receptor superfamily (TNFRSF17) . BCMA contains one extracellular cysteine rich domain; as well as TACI. Human BCMA is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain; a 23 aa transmembrane domain; and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity. BCMA is mainly expressed in immune organs and mature B cell lines. BCMA appears to be localized to the Golgi compartment. BCMA may play an important role in B cell development; function and regulation.

Abbreviation

BCMA; TNFRSF17

Synonyms

B-cell maturation protein; CD269; TNFRSF17; Tumor necrosis factor receptor superfamily member 17

UniProt

Q02223

Accession Number

Q02223

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Met1-Ala54

Field of Research

Signal Transduction; Cancer; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.