Recombinant Human CRADD/RAIDD Protein
Product Specifications
Background
Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues; with particularly high expression in the adult heart; testis; liver; skeletal muscle; fetal liver; and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2; and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numerous tissues. Defects in CRADD will result in mental retardation.
Abbreviation
CRADD; RAIDD
Synonyms
CRADD; Caspase and RIP Adapter with Death Domain; Death Domain-Containing Protein CRADD; RAIDD; RIP-Associated Protein with A Death Domain
UniProt
P78560
Accession Number
P78560
Expression System
E.coli
Tag
None
Sequence
Met1-Glu199
Field of Research
Cell biology; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
23 kDa
Observed Molecular Weight
21 kDa
Species
Human
Available Sizes
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