Recombinant Human Cathepsin S/CTSS Protein (His Tag)
Product Specifications
Background
Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease (AD) and Down Syndrome (DS) .
Abbreviation
Cathepsin S, CTSS
Synonyms
CTSS; Cathepsin S; MGC3886
UniProt
P25774
Accession Number
AAH02642.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Gln17-Ile331
Field of Research
Tags & Cell Markers; Cell biology; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
36.9 & 25 & 11.2 kDa
Observed Molecular Weight
37 - 40 & 26 - 28 & 14 - 16 kDa
Formulation
Supplied as a 0.2 µm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
Species
Human
Available Sizes
Curated Selection
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