Recombinant Human CCL8/MCP-2 Protein

Product Specifications

Background

Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3; respectively. All three MCP proteins are monocyte chemoattractants. CCL8 is chemotactic for and activates many different immune cells; including mast cells; eosinophils and basophils; which are implicated in allergic response; and monocytes; T cells; and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors including CCR1; CCR2B and CCR5.

Abbreviation

CCL8; MCP-2

Synonyms

C-C Motif Chemokine 8; CCL8; HC14; MCP-2; MCP2; Monocyte Chemoattractant Protein 2; Monocyte Chemotactic Protein 2; SCYA10; SCYA8; Small-Inducible Cytokine A8

UniProt

P80075

Accession Number

P80075

Expression System

E.coli

Tag

None

Sequence

Gln24-Pro99

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.