Recombinant Human CD86/B7-2 Protein (Val185Ile, His Tag)

The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type (immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.

LAB; ETC; FUN; CTLA-4 Counter-Receptor B; Early T-cell costimulatory molecule; CD28LG; B7-2; B7.2; B70; CD28LG2; LAB72; CD86; Activation B7-2 antigen; BU63; CTLA-4 Counter-Receptor B7.2; Early T-cell costimulatory molecule 1; ETC-1; FUN-1; T-lymphocyte activation antigen CD86; B7-2; Activation B7-2 antigen 3; B7 2; B72 antigen; B-lymphocyte activation antigen B7-2; B-lymphocyte activation antigen B7-2 2; CD28 antigen ligand 2; CD28 antigen ligand 2 2; Cd28l2; CD86 antigen; CD86 molecule; CLS1; CTLA-4 counter-receptor B7.2 2; FUN 1; Ly58; Ly-58; MB7; MB7-2; Membrane glycoprotein; MGC34413; TS/A-2

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.