Recombinant Human Dectin-1/CLEC7A Protein (Fc Tag)

Product Specifications

Background

Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection.

Abbreviation

Dectin-1; CLEC7A

Synonyms

BGR; Beta-glucan receptor; CANDF4; CD369; CLEC7A; CLECSF12; CLECSF12DC-associated C-type lectin 1; DECTIN1; DECTIN1CANDF4; Dectin-1; Dectin1

UniProt

Q9BXN2

Accession Number

Q9BXN2

Expression System

HEK293 Cells

Tag

N-Fc

Sequence

Thr66-Met247

Field of Research

Immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 85 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.