Recombinant Human HAI-2/SPINT2 Protein (His Tag)

Product Specifications

Background

Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI2) is a single-pass type I membrane protein and contains two BPTI/Kunitz inhibitor domains. The first Kunitz domain is mainly responsible for the inhibitory activity against hepatocyte growth factor activator (HGFA) . HAI2 is expressed in placenta, kidney, pancreas, prostate, testis, thymus and trachea. HAI2 serves as a inhibitor of HGF activator. It also inhibits plasmin, plasma and tissue kallikrein and factor XIa. Defects in HAI2 are the cause of diarrhea type 3 (DIAR3), also known as congenital sodium diarrhea (CSD) .

Abbreviation

HAI-2; SPINT2

Synonyms

HAI-2; HAI2; Hepatocyte Growth Factor Activator Inhibitor Type 2; KOP; Kunitz-Type Protease Inhibitor 2; Placental Bikunin; SPINT2

UniProt

O43291

Accession Number

O43291

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala28-Lys197

Field of Research

Cell biology; Neuroscience; Developmental Biology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.