Recombinant Human HMGB1 Protein
Product Specifications
Background
High mobility group protein B1 is a member of the HMGB family consisting of three members; HMGB1; HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein; HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile; it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte; T cell; dendritic cell activities in inflammatory responses.
Abbreviation
HMGB1
Synonyms
HMG-1; HMG1; HMGB1; High Mobility Group Protein 1; High Mobility Group Protein B1
UniProt
P09429
Accession Number
P09429
Expression System
E.coli
Tag
None
Sequence
Met1-Phe89
Field of Research
Epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/uhc0lp
Product MSDS
https://789.bio/eb/zTiLiP
Calculated Molecular Weight
10.4 kDa
Observed Molecular Weight
14 kDa
Species
Human
Available Sizes
Curated Selection
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