Recombinant Human Interleukin-2/IL-2 Protein (Mutant)
Product Specifications
Background
Interleukin-2 (IL-2) is an interleukin; a type of cytokine signaling molecule in the immune system; belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells; NK cells; lymphokine-activated killer cells; monocytes; macrophages and oligodendrocytes. New research has shown that IL-2 mutant reduced toxicity while being more potent at stimulating anti-tumor effector immune cells.
Abbreviation
Interleukin-2; IL-2
Synonyms
IL2; IL-2; TCGF; lymphokine; IL3; IL4; IL5; IL6; Aldesleukin; IL-2lymphokine; interleukin-2; Proleukin; interleukin 2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; IL 2; IL2; Interleukin 2; interleukin2; Involved in regulation of T cell clonal expansion; Lymphokine; POIL2; T Cell Growth Factor; TCGF
UniProt
P60568
Accession Number
P60568
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ala21-Thr153 (L100F, R101D, L105V, I106V, I112F)
Applications
Cell culture
Field of Research
Immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
50
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
16.5 kDa
Observed Molecular Weight
16&18 kDa
Species
Human
Available Sizes
Documents
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