Recombinant Human IFN-λ3/IL-28B Protein

Product Specifications

Background

Interleukin-28B; also known as Cytokine Zcyto22; Interferon lambda-3; Interferon lambda-4; IFNL3; IFNL4; ZCYTO22 and IL28B; is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition; IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Abbreviation

IFN-λ3; IL-28B

Synonyms

Cytokine Zcyto; ZCYTO; IFNL3; IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C; IL28B; IL28C; Cytokine Zcyto22; IFNL4; IFN-lambda 3; interferon lambda 3; Interferon Lambda-3; Interferon Lambda-4; Interleukin-28B; Interleukin-28C; ZCYTO22

UniProt

Q8IZI9

Accession Number

Q8IZI9

Expression System

HEK293 Cells

Tag

None

Sequence

Val22-Val196

Field of Research

Signal Transduction; Microbiology; immunology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.