Recombinant Human IL4RA/CD124 Protein (mFc Tag)

Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glycoprotein in the class I cytokine receptor family. Mature human IL4-Ra consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a cytokine binding region and one fibronectin type III domain; a 24 aa transmembrane segment; and a 569 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif. IL4-Ra plays an important role in Th2-biased immune responses; alternative macrophage activation; mucosal immunity; allergic inflammation; tumor progression; and atherogenesis. Soluble forms of IL4-Ra; generated by alternate splicing or proteolysis; retain ligand binding properties and inhibit IL-4 bioactivity.

582J; IL4R; CD124; IL-4RA; IL4RA; IL-4 receptor subunit alpha; IL-4-binding protein; IL4-BP; IL-4R subunit alpha; IL-4R-alpha; Interleukin-4 receptor subunit alpha;582J2.1; IL-4Rα IL 4R alpha; IL4R nirs variant 1; IL4RA; Interleukin 4 receptor; Interleukin 4 receptor alpha chain; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.