Recombinant Human IL-6/Interleukin-6 Protein

Cytokines of the IL6/GCSF/MGF family are glycoproteins of about 170 to 180 amino acid residues that contain four conserved cysteine residues involved in two disulfide bonds. They have a compact, globular fold (similar to other interleukins), stabilized by the 2 disulfide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist; the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.

IFNB; Interleukin HP; Interferon Beta; B-Cell Stimulatory Factor; IFN-Beta; B-cell hybridoma growth factor; B-Cell Stimulatory Factor 2; BSF2; BSF-2; CDF; CTL Differentiation Factor; HGF; HSF; Hybridoma Growth Factor; IFN-Beta-2; IL-6; Interferon Beta-2; Interleukin 6; Interleukin HP-1; Interleukin-6; IL6; IFNB2; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; Hepatocyte stimulatory factor; Hybridoma growth factor Interferon beta-2; IL 6; Interferon beta 2; Interleukin 6 (interferon beta 2) ; Interleukin BSF 2; Interleukin-6; IL-6; B-cell hybridoma growth factor; Interleukin HP-1

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.