Recombinant Human LAG3/CD223 Protein (Fc Tag)
Product Specifications
Background
Human Lymphocyte activation gene 3 protein (LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule; LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
Abbreviation
LAG3; CD223
Synonyms
CD223; LAG-3; LAG3; Lymphocyte activation gene 3 protein; Protein FDC
UniProt
P18627
Accession Number
P18627
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Leu23-Leu450
Applications
ELISA
Field of Research
Immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
50
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Product Datasheet
https://789.bio/ea/u1rrdp
Product MSDS
https://789.bio/eb/qj14KC
Calculated Molecular Weight
73.3 kDa
Observed Molecular Weight
70-90 kDa
Formulation
24
Species
Human
Available Sizes
Curated Selection
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