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Recombinant Human METAP1 Protein

Product Specifications

Background

Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G (2) /M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.

Abbreviation

METAP1

Synonyms

MAP 1; MAP1A; METAP1; MetAP 1; MetAP1A; Methionine aminopeptidase 1; Peptidase M 1

UniProt

P53582

Accession Number

P53582

Expression System

E.coli

Tag

None

Sequence

Met1-Phe386

Field of Research

Signal Transduction; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Product Datasheet

https://789.bio/ea/e94tlg

Product MSDS

https://789.bio/eb/9GSmD0

Calculated Molecular Weight

43.2 kDa

Observed Molecular Weight

38-50 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, pH 8.0.

Species

Human

Available Sizes

Curated Selection

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