Recombinant Human NRCAM Protein (Fc Tag)

Product Specifications

Background

Neuronal cell adhesion molecule (NRCAM) is a single-pass type I membrane protein , containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. NrCAM is engaged in such biological processes as axonal fasciculation, cell-cell adhesion, central nervous system development, clustering of voltage-gated sodium channels, neuron migration, positive regulation of neuron differentiation, regulation of axon extension, and synaptogenesis. It also may play a role in the molecular assembly of the nodes of Ranvier. NrCAM effects are also linked with different recognition processes and signal transduction pathways regulating cell differentiation, proliferation, or migration.

Abbreviation

NRCAM

Synonyms

KIAA0343; Neuronal cell adhesion molecule; Neuronal surface protein Bravo; Ng-CAM-related; Nr-CAM; gCAM-related cell adhesion molecule; gCAM-related cell adhesion molecule ; hBravo

UniProt

Q92823

Accession Number

AAI15737.1

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln25-Asn600

Field of Research

Neuroscience

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.