Recombinant Human TrkB/NTRK2 Protein (His Tag)

Product Specifications

Background

The TRK Family of Tyrosine Kinase Receptor consists of 3 members: TrkA, TrkB and TrkC. The three TRK family proteins have different ligand specificities. They connect to different neurotrophins, including NGF, BDNF, NT-3NT-4/5. TRKA binds NGF, TRKB binds BDNF and NT-3, TRKC binds NT-4/5. At the protein sequence level, human and rat TRKB have greater than 90% sequence identity and the proteins exbihit cross-species activity. TRKB is primarily expressed in the nervous system and it also expression in a wide variety of tissues with low levels.

Abbreviation

TrkB; NTRK2

Synonyms

BDNF/NT-3 Growth Factors Receptor; GP145-TrkB; NTRK2; Neurotrophic Tyrosine Kinase Receptor Type 2; TRKB; Trk-B; TrkB Tyrosine Kinase; Tropomyosin-Related Kinase B

UniProt

Q16620

Accession Number

Q16620

Expression System

HEK293 Cells

Tag

C-His

Sequence

Cys32-His430

Field of Research

Neuroscience; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.