Recombinant Human CD155/PVR/NECL5 Protein (His Tag)

Product Specifications

Background

Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV) ; an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.

Abbreviation

CD155; PVR; NECL5

Synonyms

CD155; NECL-5; Nectin-Like Protein 5; PVR; PVS; Poliovirus Receptor

UniProt

A0A0C4DG49

Accession Number

NP_006496

Expression System

HEK293 Cells

Tag

C-His

Sequence

Trp21-Asn343

Applications

BLI

Field of Research

Microbiology

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Loaded Human TIGIT-Fc on Protein A Biosensor, can bind Human PVR-His with an affinity constant of 4.22 nM as determined in BLI assay.

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

36.1 kDa

Observed Molecular Weight

58 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Species

Human

Available Sizes

Documents

Product Datasheet

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