Recombinant Human β-NGF/NGFB Protein (with pro peptide)
Product Specifications
Background
The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges; whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
Abbreviation
Β-NGF; NGFB
Synonyms
Beta-NGF; Beta-Nerve Growth Factor; NGF; NGFB
UniProt
P01138
Accession Number
P01138
Expression System
E.coli
Tag
None
Sequence
Glu19-Ala241
Field of Research
Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
25 kDa
Observed Molecular Weight
30 kDa
Species
Human
Available Sizes
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