Recombinant Human RHEB Protein (GST Tag)
Product Specifications
Background
GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored; cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle; and it is vital in the regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. RHEB stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling; and it activates the protein kinase activity of mTORC1. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form; farnesylation of the protein is required for this activity.
Abbreviation
RHEB
Synonyms
GTP-Binding Protein Rheb; RHEB; RHEB2; Ras Homolog Enriched in Brain
UniProt
Q15382
Accession Number
Q15382
Expression System
E.coli
Tag
N-GST
Sequence
Met1-Met184
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/hodpps
Product MSDS
https://789.bio/eb/4K0SG8
Calculated Molecular Weight
20.4 kDa
Observed Molecular Weight
45 kDa
Species
Human
Available Sizes
Curated Selection
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