Recombinant Human TPP1/CLN2 Protein (His Tag)
Product Specifications
Background
Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2) .
Abbreviation
TPP1; CLN2
Synonyms
CLN2; Cell Growth-Inhibiting Gene 1 Protein; GIG1; LPIC; Lysosomal Pepstatin-Insensitive Protease; SCAR7; TPP-1; TPP1; Tripeptidyl Aminopeptidase; Tripeptidyl-Peptidase 1
UniProt
O14773
Accession Number
AAH14863.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ser20-Pro563
Field of Research
Cell biology; Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
60.4 kDa
Observed Molecular Weight
74 kDa
Formulation
2
Species
Human
Available Sizes
Documents
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