Recombinant Human TPBG/5T4 Protein (His Tag)
Product Specifications
Background
Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Abbreviation
TPBG;5T4
Synonyms
5T4 Protein;5T4AG Protein; Human; M6P1 Protein; WAIF1 Protein
UniProt
Q13641
Accession Number
Q13641
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ser32-Ser355
Field of Research
Cancer; Developmental Biology; immunology; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/ephu54
Product MSDS
https://789.bio/eb/SWv5S4
Calculated Molecular Weight
36.1 kDa
Observed Molecular Weight
55-80 kDa
Species
Human
Available Sizes
Curated Selection
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