Recombinant Human HOXB4 Protein (His Tag)
Product Specifications
Background
Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
Abbreviation
HOXB4
Synonyms
HOX2F; HOXB4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F; Homeobox protein Hox-B4
UniProt
P17483
Accession Number
P17483
Expression System
E.coli
Tag
N-His
Sequence
Met1-Leu251 (Leu175Asp, Glu176Lys, Glu178Lys)
Field of Research
Epigenetics and nuclear signal; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
29.8 kDa
Observed Molecular Weight
36 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 4mM HCl.
Species
Human
Available Sizes
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