Recombinant Human Fas/CD95/TNFRSF6 Protein (His Tag)
Product Specifications
Background
FAS is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
Abbreviation
Fas; CD95; TNFRSF6
Synonyms
ALPS1A; APO-1; APT1; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; CD95; FAS1; FASLG receptor; FASTM; TNFRSF6 and FAS; Tumor necrosis factor receptor superfamily member 6
Accession Number
P25445
Expression System
HEK293 Cells
Tag
C-His
Sequence
Gln26-Asn173
Field of Research
Cell biology; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/mquipk
Product MSDS
https://789.bio/eb/5uXDWD
Calculated Molecular Weight
17.7 kDa
Observed Molecular Weight
22-35 kDa
Species
Human
Available Sizes
Curated Selection
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