Recombinant Human GFRRA2 Protein (His Tag)

Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and Neurturin, play key roles in the control of vertebrate neuronal survivial and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2, and GFRα-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and Neurturin-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR-3 is expressed only during development. GFRα-2 binds Neurturin and mediates activation of RET receptor tyrosine kinase by both Neurturin and GDNF.

GDNF Family Receptor Alpha-2; GDNF Receptor Alpha-2; GDNF Receptor Beta; GDNFR-Alpha-2; GDNFR-Beta; GDNFRB; GFR-Alpha-2; GFRA2; NRTNR-Alpha; NTNR-Alpha; Neurturin Receptor Alpha; RET Ligand 2; RETL2; TGF-Beta-Related Neurotrophic Factor Receptor 2; TRNR2

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.