Recombinant Human PGD Protein (Human Cells, His Tag)
Product Specifications
Background
6-phosphogluconate dehydrogenase (PGD) is a cytoplasm-located protein; and belongs to the 6-phosphogluconate dehydrogenase family. 6PGD is the second dehydrogenase in the pentose phosphate shunt. It catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2; with concomitant reduction of NADP to NADPH. Mutations within the gene coding this enzyme result in 6-phosphogluconate dehydrogenase deficiency; an autosomal hereditary disease effecting the red blood cells.
Abbreviation
PGD
Synonyms
6-phosphogluconate dehydrogenase;6PGD; Decarboxylating; PGD; PGDH
UniProt
P52209
Accession Number
P52209
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-Ala483
Field of Research
Signal Transduction; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
54.2 kDa
Observed Molecular Weight
58 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Species
Human
Available Sizes
Documents
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