Recombinant Human Kallikrein 11/KLK11 Protein (His Tag)
Product Specifications
Background
Human Kallikrein 11 (KLK11) is a member of tissue kallikrein family which are extracellular serine proteases consisting of 15 members. Two isoforms of KLK11 are differentially expressed. Isoform 1 is predominantly expressed in brain and isoform 2 is preferentially expressed in prostate. Isoform 1 consists of a signal peptide; a short pro peptide and the mature chain.Isoform 2 contains an extra 32 amino acid N terminal to full-length isoform 1.KLK11 is a novel marker for ovarian and prostate cancer carcinomas. KLK11 can be activated by thermolysin and is active against a thioester substrate.
Abbreviation
Kallikrein 11; KLK11
Synonyms
Hippostasin; KLK11; Kallikrein-11; PRSS20; Serine Protease 20; TLSP; Trypsin-Like Protease; hK11
Accession Number
AAH22068
Expression System
HEK293 Cells
Tag
C-His
Sequence
Glu19-Asn250
Field of Research
Signal Transduction; Cell biology; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
26.3 kDa
Observed Molecular Weight
38 kDa
Formulation
2
Species
Human
Available Sizes
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