Recombinant Human P4HB Protein (His Tag)
Product Specifications
Background
Protein Disulfide-Isomerase (P4HB) is an endoplasmic reticulum lumen protein that belongs to the protein disulfide isomerase family. P4HB contains two thioredoxin domains and catalyzes the formation, breakage, and rearrangement of -S-S- bonds in proteins. P4HB is involved in hydroxylation of prolyl residues in preprocollagen. P4HB has the ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner. P4HB plays a role in both the influx and efflux of S-nitrosothiol-bound nitric oxide.
Abbreviation
P4HB
Synonyms
Cellular Thyroid Hormone-Binding Protein; DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB; Prolyl 4-Hydroxylase Subunit Beta; Protein Disulfide-Isomerase; p55
Accession Number
P07237
Expression System
HEK293 Cells
Tag
C-His
Sequence
Asp18-Lys505
Field of Research
Signal Transduction; Tags & Cell Markers; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
55.9 kDa
Observed Molecular Weight
65 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
Human
Available Sizes
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