Recombinant Human PLA2G7/Lp-PLA2 Protein (His Tag)
Product Specifications
Background
Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive products. PAFAH is produced by inflammatory cells and hydrolyzes oxidised phospholipids in LDL. PAFAH has been implicated in the development of atherosclerosis and has also been identified as a marker for cardiac disease. PAFAH might have a major physiologic effect in the presence of inflammatory bodily responses. PAFAH alters the action of PAF by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. PAFAH has specificity for substrates with a short residue at the sn-2 position.
Abbreviation
PLA2G7; Lp-PLA2
Synonyms
1-alkyl-2-acetylglycerophosphocholine esterase;2-acetyl-1-alkylglycerophosphocholine esterase; EC 3.1.1; EC 3.1.1.47; Group-VIIA phospholipase A2; LDL-PLA (2) ; LDL-PLA2; LDL-associated phospholipase A2; Lp; LpPLA2; gVIIA-PLA2; lipoprotein-associated phospholipase A2
UniProt
Q13093
Accession Number
AAH38452.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Phe22-Asn441
Field of Research
Immunology, Cardiovascular
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
48.8 kDa
Observed Molecular Weight
50-65 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mM NaAc, 150mM NaCl, 50% Glycerol, pH5.0.
Species
Human
Available Sizes
Documents
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