Recombinant Human IL10RB/IL10R2 Protein (His Tag)
Product Specifications
Background
IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.
Abbreviation
IL10RB; IL10R2
Synonyms
CRFB; Interleukin-10 receptor subunit; Cytokine receptor class-II member; Cytokine receptor family 2 member; CRF2; IL-10R; CDW210B; CRF2-4; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; IL-10R2; Interleukin-10 receptor subunit 2; Interleukin-10 receptor subunit beta (IL10RB) ; IL10RB; CRFB4; D21S58; D21S66; CRF2-4; IL-10Rb; Cd210; CRF2 4; Cytokine receptor class II; Cytokine receptor class II CRF2 4; Cytokine receptor family II member 4; I10R2; IL-10 receptor subunit beta; IL-10R subunit 2; IL-10R subunit beta; IL10R2; IL-10RB; Interleukin 10 receptor beta; Interleukin-10 receptor subunit beta
UniProt
Q08334
Accession Number
Q08334
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met20-Ser220
Field of Research
Signal Transduction; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/vhtm5c
Product MSDS
https://789.bio/eb/r1GKmH
Calculated Molecular Weight
24.5 kDa
Observed Molecular Weight
48 kDa
Species
Human
Available Sizes
Curated Selection
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