Recombinant Human SH2D1A/SAP Protein (His Tag)
Product Specifications
Background
SH2 Domain-Containing Protein 1A, (SH2D1A) contains one SH2 domain and a short tail and is localized in the cytoplasm. SH2D1A is expressed at a high level in the thymus and the lung, with lower expression levels in the spleen and the liver. SH2D1A acts as an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. In addition, SH2D1A mediates interaction between FYN and SLAMF1. It is also thought to regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Abbreviation
SH2D1A; SAP
Synonyms
DSHP; Duncan Disease SH2-Protein; EBVS; IMD5; LYP; MTCP1; SAP/SH2D1A; SH2 Domain-Containing Protein 1A; SH2D1A; SLAM-Associated Protein; Signaling Lymphocytic Activation Molecule-Associated Protein; T-Cell Signal Transduction Molecule SAP; XLP; XLPD; XLPD1
Accession Number
O60880
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Pro128
Field of Research
Cardiovascular; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
16.4 kDa
Observed Molecular Weight
16 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5.
Species
Human
Available Sizes
Documents
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